This review provides an overview of experimental animal models used in hypertension research, emphasizing careful selection and cautious extrapolation to human disease.
Cautious extrapolation from animal hypertension models to patients advised; leaves open optimal model selection in research.
Hypertension is the most important risk factor for cardiovascular diseases such as stroke, coronary artery disease and sudden cardiac death. Depending on the etiology, there are many different hypertension types, these types of hypertension are investigated in different models.The use of experimental animal models has provided valuable information on many aspects of hypertension such as etiology, pathophysiology, complication and treatment. For this purpose, appropriate experimental method and animal to be used in these studies should be selected considering the design of the study and its limitations. Since significant differences exist between hypertension in experimental animals and human hypertension the extrapolation of results obtained from experimental studies to humans is extremely important. In this review, various experimental models which are used in hypertension research were evaluated.
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REŞİTOĞLU et al. (2016) studied this question.
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