The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats

Dahl salt-sensitive (DSS) rats fed low salt (LS, 0.3% NaCl) or high salt (HS, 8% NaCl) diets

AC3174 (1.7 pmol/kg/min) via subcutaneous infusion for 4 weeks, alone or in combination with captopril (150 mg/kg/day)

Vehicle (in HS rats), GLP-1 (25 pmol/kg/min), captopril alone, and low salt diet

Survival, systolic blood pressure, cardiac parameters (posterior wall thickness, LV mass, LV wall stress), insulin resistance (fasting insulin, HOMA-IR), and renal function/morphologysurrogate