Key result
In Dahl salt-sensitive rats on a high-salt diet, high-dose Ac-SDKP significantly attenuated albuminuria (57 vs 94 mg/24 h; P<0.05) and prevented renal damage without affecting blood pressure.
Why the study?
Does Ac-SDKP prevent renal damage and albuminuria in salt-sensitive rats on a high-salt diet?
Does Ac-SDKP prevent renal damage and albuminuria in salt-sensitive rats on a high-salt diet?
Absolute Event Rate: 57% vs 94%
p-value: p=<0.05
Ac-SDKP prevents high-salt-induced renal damage and albuminuria in salt-sensitive rats independent of blood pressure changes.
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Ac-SDKP may confer BP-independent renal protection in salt-sensitive models; leaves open translation to human hypertension.
Worou et al. (2015) studied Salt-sensitive hypertension and renal damage. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) vs. vehicle was evaluated on albuminuria (p=<0.05). In Dahl salt-sensitive rats on a high-salt diet, high-dose Ac-SDKP significantly attenuated albuminuria (57 vs 94 mg/24 h; P<0.05) and prevented renal damage without affecting blood pressure.
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