Key result
Ac-SDKP prevented the increase in left ventricular interstitial collagen fraction in hypertensive rats (5.4% vs 10.1% with vehicle; P<0.001) without affecting blood pressure or cardiac hypertrophy.
Why the study?
Does Ac-SDKP prevent left ventricular hypertrophy and interstitial collagen deposition in rats with 2-kidney, 1-clip hypertension?
Does Ac-SDKP prevent left ventricular hypertrophy and interstitial collagen deposition in rats with 2-kidney, 1-clip hypertension?
Absolute Event Rate: 5.4% vs 10.1%
p-value: p=<0.001
Ac-SDKP prevents left ventricular collagen deposition and cellular infiltration in hypertensive rats independently of blood pressure, suggesting it may mediate some cardioprotective effects of ACE inhibitors.
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Ac-SDKP attenuates LV fibrosis in hypertensive rats; leaves open translation to human cardioprotection or ACE inhibitor mechanisms.
Rhaleb et al. (2001) studied 2-kidney, 1-clip (2K-1C) hypertension. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) vs. Vehicle was evaluated on Left ventricular interstitial collagen fraction (p=<0.001). Ac-SDKP prevented the increase in left ventricular interstitial collagen fraction in hypertensive rats (5.4% vs 10.1% with vehicle; P<0.001) without affecting blood pressure or cardiac hypertrophy.
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