Why the study?
Does Ac-SDKP reduce DNA and collagen synthesis in rat cardiac fibroblasts?
Does Ac-SDKP reduce DNA and collagen synthesis in rat cardiac fibroblasts?
Ac-SDKP inhibits DNA and collagen synthesis in rat cardiac fibroblasts, suggesting it may mediate the anti-fibrotic and cardioprotective effects of ACE inhibitors.
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Ac-SDKP may inhibit rat fibroblast proliferation; hypothesis-generating for ACE inhibitor anti-fibrotic effects, requires in vivo confirmation.
Rhaleb et al. (2001) studied this question.
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