Key result
Exogenous Ac-SDKP mimicked the anti-inflammatory and antifibrotic effects of ACE inhibitors in Ang II-induced hypertension, independent of hemodynamic effects.
Why the study?
Does Ac-SDKP mimic the anti-inflammatory and antifibrotic effects of ACE inhibitors in rats with Ang II-induced hypertension?
Population
Rats with Angiotensin II-induced hypertension
Comparison
Ac-SDKP or captopril vs Control rats and rats receiving Angiotensin II…
Design
Preclinical
Authors
Loading...
Ac-SDKP effects in Ang II rats extend mechanistic insight; human trials needed before considering targeted therapy.
Does Ac-SDKP mimic the anti-inflammatory and antifibrotic effects of ACE inhibitors in rats with Ang II-induced hypertension?
Ac-SDKP mimics the anti-inflammatory and antifibrotic effects of ACE inhibitors in a rat model of hypertension, independent of hemodynamic changes.
Rasoul et al. (2004) studied Hypertension. Ac-SDKP and captopril vs. Controls and Ang II alone was evaluated on LV cell proliferation, inflammatory cell infiltration, cytokine expression, hypertrophy and fibrosis. Exogenous Ac-SDKP mimicked the anti-inflammatory and antifibrotic effects of ACE inhibitors in Ang II-induced hypertension, independent of hemodynamic effects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: