Why the study?
Does N-acetyl-seryl-aspartyl-lysyl-proline mediate the antifibrotic and anti-inflammatory effects of captopril in a rat model of aldosterone-salt-induced hypertension?
Does N-acetyl-seryl-aspartyl-lysyl-proline mediate the antifibrotic and anti-inflammatory effects of captopril in a rat model of aldosterone-salt-induced hypertension?
The antifibrotic and anti-inflammatory effects of ACE inhibitors on the heart and kidneys in hypertension are partially mediated by N-acetyl-seryl-aspartyl-lysyl-proline.
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Ac-SDKP mediation of ACEI organ protection merits human investigation; hypothesis-generating in rat model, should not change practice.
Peng et al. (2007) studied this question.
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