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Purified parathyroid hormone can be readily tritiated by reaction with high specific activity tritiated methyl ester of acetamidate. The reaction proceeds easily under mild conditions and a fully active acetamidino derivative of parathyroid hormone is obtained as determined by the serum calcium assay and the renal-adenylate cyclase system. The reaction produces no detectable side products of a protein or polypeptide nature and the acetamidino derivative appears radiochemically homogeneous upon disc electrophoresis.
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Zull et al. (1972) studied this question.
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