Key result
Acute STEMI in patients with normal QRS duration was associated with significantly prolonged left ventricular dyssynchrony compared to healthy controls (mean Ts-SD-12 43.2 vs 23.0 ms, p=0.0001).
Case-Control (n=62)
No
Real-time 3D echocardiography demonstrates that significant left ventricular dyssynchrony occurs early after acute STEMI, even in patients with normal QRS duration.
LV dyssynchrony may occur early post-STEMI despite normal QRS; hypothesis-generating for 3D echo utility in risk stratification.
Background: The aim of this study was to assess left ventricular dyssynchrony after acute ST elevated myocardial infarction (STEMI) in patients with normal QRS duration. Real time 3D echocardiography (RT3DE) with triplane tissue synchronization imaging (TSI) used to identify segmental left ventricular systolic velocity in ejection phase to evaluate LV dyssynchrony in patients with STEMI and the findings were compared with control.Materials and methods: RT3DE with triplane TSI was performed within 4 days of AMI after thrombolysis or primary PCI in 31 patients and compared with 31 agematched controls. Regional myocardial velocities were assessed in 12 segments in ejection phase, and the corresponding time to peak systolic velocity (Ts) was measured. To assess LV dyssynchrony Ts-4, Ts-6, Ts- SD-6, Ts-12 and Ts-SD-12 were computed by offline dedicated software semi-automatically.Results: The dyssynchrony parameters were significantly prolonged in patients with AMI. Among the dyssynchrony parameters TS-SD-12 was better indicator of LV dyssynchrony. The Ts-SD-12 was significantly prolonged in the STEMI group when compared with controls. In patients with acute STEMI mean Ts-SD-12 was 43.2±19.1 milliseconds whereas in control group it was 23.0 ±6.5 milliseconds (p<0.05). The Ts-SD-12 was prolonged in patients with Anterior than Inferior STEMI as follows respectively 45.9± 17.6 and 40.0± 21 milliseconds.Conclusions: Triplane TSI by RT3DE is useful in evaluating LV dyssynchrony in patients with acute STEMI and even in those with normal QRS duration there is significant left ventricular dyssynchrony early after STEMI.
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Alam et al. (2016) conducted a case-control in Acute ST Elevated Myocardial Infarction (STEMI) with normal QRS duration (n=62). Acute STEMI vs. Healthy controls was evaluated on Left ventricular dyssynchrony measured by standard deviation of time to peak systolic velocity of 12 LV segments (Ts-SD-12) (p=0.0001). Acute STEMI in patients with normal QRS duration was associated with significantly prolonged left ventricular dyssynchrony compared to healthy controls (mean Ts-SD-12 43.2 vs 23.0 ms, p=0.0001).
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