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Experimental study demonstrates high enantioselectivity in dialkylzinc additions to acyclic nitroalkenes, highlighting a new catalytic pathway to beta-amino acid derivatives.
Using chiral phosphoramidite ligand (S,R,R)-L1 in the conjugate addition to acyclic nitroalkenes for the first time, we obtained enantioselectivities up to 98%. The use of acyclic substrates with different dialkylzinc reagents provides a catalytic enantioselective route to (functionalized) beta2-amino aldehydes, acids, and alcohols.
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Duursma et al. (2003) studied this question.
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