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A breakthrough in copper-catalyzed enantioselective Michael additions was achieved recently by Feringa et al. by using the chiral phosphorus amidite 1. With few mol % of this ligand and copper(II) triflate, highly enantioselective 1,4-additions of diorganozinc reagents to numerous cyclic enones can be carried out.
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Norbert Krause (1998) studied this question.
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