Key result
Longer-term L-citrulline supplementation (≥8 weeks) reduced systolic blood pressure in middle-aged and elderly populations (SMD -0.41; 95% CI -0.84 to 0.02; p=0.06).
Why the study?
This study aimed to investigate the effect of L-citrulline supplementation on blood pressure in middle-aged and elderly populations.
Does L-citrulline supplementation reduce blood pressure in middle-aged and elderly populations at risk of hypertension?
Meta-Analysis (n=150)
Does L-citrulline supplementation reduce blood pressure in middle-aged and elderly populations at risk of hypertension?
Standardized Mean Difference: -0.41 (95% CI -0.84–0.02)
p-value: p=0.06
Higher dosage (≥6 grams) and longer duration (≥8 weeks) of L-citrulline supplementation may have potential blood pressure lowering effects in middle-aged and elderly populations.
No overall BP benefit; leaves open potential effects of higher-dose, longer-term regimens for targeted trials.
Purpose This paper aims to investigate the effect of L-citrulline supplementation on blood pressure (BP) in middle-aged and elderly populations. Design/methodology/approach Three electronic databases, namely, Google Scholar, PubMed and Scopus, were searched from 1990 to November 2020. Random effects model analysis was applied for quantitative data synthesis, and 6 trials with 150 participants were identified and included in the analysis. Findings Results showed an overall non-significant effect of L-citrulline supplementation on both systolic BP (SBP) and diastolic BP (DBP) in middle-aged and elderly participants. However, stratified analysis indicated a significant reduction in SBP (SMD: −0.41, 95% CI: −0.84, 0.02; p = 0.06, heterogeneity p = 0.41; I2 = 10%) but not in DBP (SMD:−0.15, 95% CI: −0.57, 0.28; p = 0.51, heterogeneity p = 0.60; I2 = 0%), following longer-term (= 8 weeks) supplementation of L-citrulline. Additionally, higher doses of L-citrulline (= 6 grams) showed a marginally significant reduction in DBP (SMD: −0.38, 95% CI: −0.78, 0.02; p = 0.06, heterogeneity p = 0.50; I2 = 0%). Originality/value In conclusion, a higher dosage and longer duration of supplementation with L-citrulline may have potential BP lowering effects in populations at an increased risk of hypertension
No takes yet. Share an insight, caveat, or question.
Jafarnejad et al. (2022) conducted a meta-analysis in increased risk of hypertension (n=150). L-citrulline supplementation was evaluated on Systolic blood pressure (SBP) following longer-term (≥ 8 weeks) supplementation (SMD -0.41, 95% CI -0.84, 0.02, p=0.06). Longer-term L-citrulline supplementation (≥8 weeks) reduced systolic blood pressure in middle-aged and elderly populations (SMD -0.41; 95% CI -0.84 to 0.02; p=0.06).
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: