Key result
Each 1-unit increase in log NT-proBNP was associated with a 1.312-fold increased risk of major adverse cardiac events at 1 year in NSTEMI patients who underwent PCI within 24 hours.
Why the study?
Does a high serum concentration of NT-proBNP predict 1-year MACE in NSTEMI patients undergoing PCI within 24 hours of chest pain onset?
Observational (n=1,373)
Yes
Does a high serum concentration of NT-proBNP predict 1-year MACE in NSTEMI patients undergoing PCI within 24 hours of chest pain onset?
NT-proBNP levels measured at emergency room admission can serve as a significant prognostic indicator for 1-year MACE in NSTEMI patients undergoing early PCI.
Admission NT-proBNP may help risk-stratify NSTEMI patients undergoing early.
Recently, N-terminal pro-brain natriuretic peptide (NTproBNP) has been widely used in the areas of diagnosis, monitoring treatment efficiency, and prognosis for various heart diseases, especially heart failure (HF). In this paper, we try to estimate the prognostic significance of NT-proBNP as a risk evaluation marker in Non-ST-segment Elevation Myocardial Infarction (NSTEMI) patients. We selected NSTEMI patients who underwent percutaneous coronary intervention (PCI) primarily using a drug-eluting stent within 24 h after the onset of chest pain. We compared incidences of major adverse cardiac events (MACE) including death, myocardial infarction (MI), stent thrombosis (ST), and target vessel revascularization (TVR) in two patient groups according to a high or low serum concentration of NT-proBNP, which was measured in the emergency room (ER). We intend to minimize selection bias selecting comparing groups, considering covariate of observed variables together using propensity score matching (PSM) and propensity score weighting (PSW) based on propensity score (PS) to control the difference in baseline characteristics between high- and low NT-proBNP groups. We found that as the log NT-proBNP value increases by 1 through a hazard function of COX’s analysis, the risk of MACE increases by 1.312 times. This result indicated that the NT-proBNP level on ER admission can be used as a significant prognostic indicator to estimate 1 year of MACE in NSTEMI patients who were treated with PCI within 24 h after the onset of chest pain.
No takes yet. Share an insight, caveat, or question.
Shon et al. (2017) conducted an observational in Non-ST-segment Elevation Myocardial Infarction (NSTEMI) (n=1,373). High serum NT-proBNP vs. Low serum NT-proBNP was evaluated on Major adverse cardiac events (MACE) including death, myocardial infarction, stent thrombosis, and target vessel revascularization (HR 1.312, 95% CI 1.014-1.699, p=0.0391). Each 1-unit increase in log NT-proBNP was associated with a 1.312-fold increased risk of major adverse cardiac events at 1 year in NSTEMI patients who underwent PCI within 24 hours.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: