Key result
Diabetic state impaired cardiac contractile function and ablated baseline gender differences in mechanical function, though young female diabetic mice retained better-preserved mechanical function.
Diabetes impairs cardiac contractile function and alters intracellular Ca2+ handling in both genders, largely ablating baseline gender differences in mechanical function, though young females may retain some functional advantage.
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Suggests possible female advantage in diabetic cardiomyopathy; hypothesis-generating and requires confirmation in human studies.
Zhang et al. (2003) studied Diabetes mellitus. Gender and diabetic state vs. Male counterparts and wild-type FVB mice was evaluated on Cardiac contractile response (mechanical and intracellular Ca2+ properties). Diabetic state impaired cardiac contractile function and ablated baseline gender differences in mechanical function, though young female diabetic mice retained better-preserved mechanical function.
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