Why the study?
Does extracellular matrix density modulate pulmonary vascular smooth muscle cell contractility?
Population
Cultured pulmonary vascular smooth muscle (PVSM) cells
Comparison
Varying densities of fibronectin coating and… vs Different densities of FN coating, resting state…
Design
Preclinical
Authors
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May link ECM density to VSMC hypercontractility; leaves open whether matrix remodeling drives pulmonary hypertension in vivo.
Does extracellular matrix density modulate pulmonary vascular smooth muscle cell contractility?
Extracellular matrix density modulates pulmonary vascular smooth muscle cell contractility, suggesting that ECM changes in hypertensive vessels may play an active role in the etiology of pulmonary hypertension.
Lee et al. (1998) studied this question.
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