May 1, 1997American Journal of Respiratory Cell and Molecular Biology

Inhibition of ERK Activation Attenuates Endothelin-Stimulated Airway Smooth Muscle Cell Proliferation

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Population

Rat airway smooth muscle (ASM) cells in culture

Design

Preclinical

Authors

AWAlyn WhelchelUniversity of Vermont JEJohn N. EvansUniversity of Vermont JPJames PosadaResolve Therapeutics (United States)

Discussion

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Implication

May support ERK inhibition as an asthma target; hypothesis-generating and requires clinical validation.

Structured PICO

Population

Rat airway smooth muscle (ASM) cells in culture

Intervention

PD98059 (small molecule inhibitor of MEK) and endothelin

Outcome

ERK2 activation and cell proliferationsurrogate

Inhibition of the ERK2 pathway attenuates endothelin-induced airway smooth muscle cell proliferation, highlighting a potential mechanistic target for asthma.

Cite This Study

Whelchel et al. (1997) studied this question.

synapsesocial.com/papers/6a8425dbac510c864ff2fabb https://doi.org/10.1165/ajrcmb.16.5.9160841

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Inhibition of ERK Activation Attenuates Endothelin-Stimulated Airway Smooth Muscle Cell Proliferation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of ERK Activation Attenuates Endothelin-Stimulated Airway Smooth Muscle Cell Proliferation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider