Key result
Administering fentanyl 7 minutes before propofol induction significantly reduced the required propofol dose (55.43 mg vs 86.77 mg) and minimized hypotension compared to a 5-minute interval.
Why the study?
The administration timing of fentanyl influences the required dose of propofol and its associated hemodynamic responses and side effects during anesthesia induction.
Does administering fentanyl 7 minutes versus 5 minutes before propofol induction reduce the required propofol dose and side effects in patients undergoing elective surgery?
Population
68 patients aged 18–65 years undergoing elective surgery under general anesthesia
Design
Randomized study
Authors
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Supports fentanyl 7 min pre-propofol to reduce dose and hypotension; extends timing optimization data for induction protocols.
RCT (n=68)
Consecutive sampling, randomized
No
Does administering fentanyl 7 minutes versus 5 minutes before propofol induction reduce the required propofol dose and side effects in patients undergoing elective surgery?
Absolute Event Rate: 55.43% vs 86.77%
p-value: p=<0.0001
Administering fentanyl 7 minutes prior to propofol induction significantly reduces the required propofol dose and the incidence of hypotension compared to a 5-minute interval.
Tripathi et al. (2025) conducted an RCT in Elective surgery under general anesthesia (n=68). Fentanyl 7 minutes before propofol induction vs. Fentanyl 5 minutes before propofol induction was evaluated on Total propofol dose necessary for loss of consciousness (p=<0.0001). Administering fentanyl 7 minutes before propofol induction significantly reduced the required propofol dose (55.43 mg vs 86.77 mg) and minimized hypotension compared to a 5-minute interval.
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