What question did this study set out to answer?

To determine whether the chemokine growth-related gene product alpha contributes to neutrophil recruitment and joint inflammation in rheumatoid arthritis.

October 1, 1995The Journal of ImmunologyOpen Access

Growth-related gene product α. A chemotactic cytokine for neutrophils in rheumatoid arthritis

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Authors

AKA E KochEli Lilly (United States)SKS L KunkelUniversity of Michigan MSManisha R. ShahVellore Institute of Technology University

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Implication

Observational study reveals elevated growth-related gene product alpha in rheumatoid arthritis joints, indicating its role in driving neutrophil infiltration.

Key Points

To determine whether the chemokine growth-related gene product alpha contributes to neutrophil recruitment and joint inflammation in rheumatoid arthritis.
Analyzed synovial tissue, synovial fluid, and plasma samples from 102 patients with rheumatoid arthritis, osteoarthritis, and other arthritic conditions.
Cultured rheumatoid synovial tissue fibroblasts and synovial fluid cells under stimulation with TNF-alpha, IL-1 beta, LPS, or PHA to quantify growth-related gene product alpha production.
Measured neutrophil chemotactic activity in synovial fluid before and after antibody neutralization of growth-related gene product alpha, IL-8, and epithelial neutrophil-activating peptide-78.
Rheumatoid arthritis synovial fluid contained significantly more gro alpha (mean 5.3 ± 1.9 ng/ml) than osteoarthritis or other arthritis fluids (mean 0.1 ng/ml; p < 0.05), and plasma levels were similarly elevated versus normal controls (mean 4.3 ± 1.8 vs 0.1 ng/ml; p < 0.05).
Gro alpha accounted for a mean of 28% of rheumatoid synovial fluid chemotactic activity for neutrophils, alongside IL-8 (36%) and epithelial neutrophil-activating peptide-78 (34%).
Simultaneous neutralization of gro alpha, IL-8, and epithelial neutrophil-activating peptide-78 in rheumatoid synovial fluids produced a mean 50% decrease in neutrophil chemotactic activity.

Cite This Study

Koch et al. (1995) studied this question.

synapsesocial.com/papers/6a8425f5ac510c864ff2fada https://doi.org/10.4049/jimmunol.155.7.3660

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Implication

Observational study reveals elevated growth-related gene product alpha in rheumatoid arthritis joints, indicating its role in driving neutrophil infiltration.

Growth-related gene product α. A chemotactic cytokine for neutrophils in rheumatoid arthritis

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Implication

Key Points

Cite This Study

Growth-related gene product α. A chemotactic cytokine for neutrophils in rheumatoid arthritis

Discussion

Member takes

Implication

Key Points

Cite This Study

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