Why the study?
Despite the widespread use of anesthesia, the mechanisms of action causing loss of consciousness and complications such as post-anesthesia cognitive impairment and temporary amnesia remain poorly understood.
Do different combinations of intravenous anesthetic drugs have different complication rates in patients undergoing surgery?
Cross-Sectional (n=368)
Do different combinations of intravenous anesthetic drugs have different complication rates in patients undergoing surgery?
Absolute Event Rate: 30.3% vs 6.4%
p-value: p=< 0.001
Different intravenous anesthetic combinations have distinct complication profiles, with propofol/fentanyl/atracurium causing more apnea and delayed recovery, and thiopental/fentanyl/atracurium causing more desaturation.
May warrant regimen-specific caution in anesthesia; leaves open comparative efficacy for randomized trials.
Background: A portion of patients exhibit subsequent cognitive impairment, including memory deficits, after undergoing anesthesia. Despite the wide use and long history of anesthesia, the mechanisms of action that cause loss of consciousness and some of the side-effects, such as temporary amnesia, are not understood. Methodology: A descriptive cross-sectional study was conducted among patients undergoing surgery in Sulaimani city, and involved 368 patients. Data, in form of questionnaire, have been collected between October 15, 2021 to February 15, 2022. (SPSS) Version 22 was used to analyzed the data. Results: In this study, 185 (50.3%) were males and 183 (49%) were females, respiratory problem in the form of apnea found in (30.3%) of patients who received (propofol, fentanyl, atracurium) compared to (6.4%) of those patients who received (propofol, (ketamine and fentanyl), atracurium) this difference was significant (P-value < 0.001), (30.3%) of patients who received (propofol, fentanyl, atracurium) (5.4%) of patients who received (thiopental, fentanyl, atracurium) and p value (< 0.001). (28.7 %) of patients who received (propofol, fentanyl, atracurium) recovered late compared to (2.3 %) of patients who received (propofol, (ketamine and fentanyl), atracurium) the difference was significant (P-value < 0.001). systolic blood pressure dropped to below 120 mmhg in (64%) patients and diastolic blood pressure dropped to below 80 mmhg in (62.8%) of patients, who received (propofol, (ketamine and fentanyl), atracurium) and compared to systolic blood pressure that dropped to below 120 mmhg in (74.3%) of patients (74.3%) of patients and diastolic blood pressure dropped to below 80 mmhg in (74.3%) of patients who received (Thiopental, fentanyl, atracurium), the differences were significant (P-value < 0.001). Finally, SpO2 level of (24.3%) of patients, who received (Propofol, (ketamine and fentanyl), atracurium), dropped to below 95% while the SpO2 level of (8.2 %) of patients who received (propofol, fentanyl, atracurium), dropped to below 95% whereas the SpO2 level of (74.3%) of patients, who received (Thiopental, fentanyl, atracurium), dropped to below 95%, these differences were significant with (P-value < 0.001). Conclusion: this study concluded that (propofol, fentanyl, atracurium) can cause respiratory problem in the form of apnea and delay recovery more than the other two sets of anesthetic drugs, while (Thiopental, fentanyl, atracurium) have effect on lowering SpO2 level more than the others sets of anesthetic drugs.
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Qurbani et al. (2022) conducted a cross-sectional in Patients undergoing surgery (n=368). Propofol, fentanyl, and atracurium vs. Propofol, ketamine and fentanyl, and atracurium was evaluated on Respiratory problem in the form of apnea (p=< 0.001).
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