Population
Mouse NIH 3T3 cells and a human cell line
Comparison
Microinjection of the encoded Asn2 form of… vs Microinjection of the deamidated Asp2 form of…
Design
Preclinical
Authors
Loading...
May influence PKA nuclear signaling in cardiac cells; leaves open functional relevance in vivo.
Site-specific in vivo deamidation of Asn2 in the PKA catalytic subunit alters its intracellular distribution, reducing its nuclear localization.
Pepperkok et al. (2000) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: