Previous investigations by one of us (Flerkó, 1954, 1957a, 1957b) have shown that in rats with anterior hypothalamic lesions the secretion of follicle-stimulating hormone (FSH) is much less inhibited after oestrogen administration than in the normal animals. These results can be explained by assuming a partly nervous »feed-back« control by which the gonadal hormones exert their influence upon the gonadotrophic activity of the anterior lobe of the hypophysis (Flerkó, 1954). Various explanations for the nervous part of this control mechanism could be advanced, the most simple, however, being the assumption of nervous elements in the anterior hypothalamus directly sensitive to oestrogen and susceptible to changes in the level of oestrogens in the blood. To test this hypothesis small amounts of oestrogen, — which given systemically would not produce any effect either on the reproductive organs or on the hypophysis, — were liberated in the immediate neighbourhood of the hypothetical oestrogen
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Flerkó et al. (1957) studied this question.