What question did this study set out to answer?

To examine the effects of adenosine and related adenine nucleotides on renal hemodynamics, excretory function, and renin secretion in the canine kidney.

March 1, 1970Circulation ResearchOpen Access

Effects of Adenosine Compounds on Renal Function and Renin Secretion in Dogs

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Population

anesthetized salt-depleted dogs

Design

Preclinical

Authors

HTHitoshi TagawaNihon University AVArthur J. VanderUniversity of Michigan

Discussion

Member takes

Implication

Adenosine effects on renal hemodynamics remain preclinical; leaves open translation to human autoregulation or renin-targeted therapies.

Key Points

To examine the effects of adenosine and related adenine nucleotides on renal hemodynamics, excretory function, and renin secretion in the canine kidney.
Infused adenosine, 5'-AMP, ATP, cyclic AMP, inosine, and inosine-5'-monophosphate directly into the renal artery of anesthetized, salt-depleted dogs.
Measured changes in renal blood flow, glomerular filtration rate, filtration fraction, sodium excretion, calculated arteriolar resistances, and renal venous renin activity.
Adenosine infusion caused an initial transient decrease in renal blood flow followed by steady-state recovery, alongside significant decreases in glomerular filtration rate, filtration fraction, sodium excretion, and renal venous renin activity.
Adenosine increased afferent arteriolar resistance and decreased efferent resistance, while 5'-AMP produced qualitatively similar but smaller hemodynamic and excretory effects.
ATP and cyclic AMP increased steady-state renal blood flow, reduced efferent resistance without altering afferent resistance, and suppressed renin secretion, whereas inosine and inosine-5'-monophosphate had no detectable effects.

Structured PICO

Population

anesthetized salt-depleted dogs

Intervention

Infusion of adenosine compounds (adenosine 20-500 µg/min, 5'-AMP 50-200 µg/min, ATP 50-500 µg/min, Cyclic AMP 1-5 mg/min, inosine 200 µg/min, or inosine-5'-monophosphate 50-200 µg/min) directly into a renal artery

Outcome

Changes in renal blood flow, glomerular filtration rate, filtration fraction, sodium excretion, and renal venous renin activitysurrogate

Adenosine and 5'-AMP induce changes in renal hemodynamics and renin secretion, suggesting they may be normal mediators of renal autoregulation and renin secretion.

Cite This Study

Tagawa et al. (1970) studied this question.

synapsesocial.com/papers/6a842f01a47fb2e1cdb29a38 https://doi.org/10.1161/01.res.26.3.327

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Effects of Adenosine Compounds on Renal Function and Renin Secretion in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of Adenosine Compounds on Renal Function and Renin Secretion in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider