Key result
Intravascular ultrasound high intensity grey level quantification (hyper + upperechogenicity) strongly correlated with Absorb scaffold residual molecular weight (r=0.78, p<0.01) in a porcine model.
Why the study?
Does IVUS quantitative echogenicity correlate with molecular weight assessment for monitoring the degradation of poly-l-lactide-acid bioresorbable scaffolds in a porcine model?
Does IVUS quantitative echogenicity correlate with molecular weight assessment for monitoring the degradation of poly-l-lactide-acid bioresorbable scaffolds in a porcine model?
IVUS high intensity grey level quantification strongly correlates with residual molecular weight and can serve as a surrogate to monitor the degradation of semi-crystalline polymer scaffolds.
IVUS echogenicity may surrogate scaffold degradation monitoring in animals; leaves open human validation before clinical use.
The objective of the study is to validate intravascular quantitative echogenicity as a surrogate for molecular weight assessment of poly-l-lactide-acid (PLLA) bioresorbable scaffold (Absorb BVS, Abbott Vascular, Santa Clara, California). We analyzed at 9 time points (from 1- to 42-month follow-up) a population of 40 pigs that received 97 Absorb scaffolds. The treated regions were analyzed by echogenicity using adventitia as reference, and were categorized as more (hyperechogenic or upperechogenic) or less bright (hypoechogenic) than the reference. The volumes of echogenicity categories were correlated with the measurements of molecular weight (Mw) by gel permeation chromatography. Scaffold struts appeared as high echogenic structures. The quantification of grey level intensity in the scaffold-vessel compartment had strong correlation with the scaffold Mw: hyperechogenicity (correlation coefficient = 0.75; P < 0.01), upperechogenicity (correlation coefficient = 0.63; P < 0.01) and hyper + upperechogenicity (correlation coefficient = 0.78; P < 0.01). In the linear regression, the R(2) for high echogenicity and Mw was 0.57 for the combination of hyper and upper echogenicity. IVUS high intensity grey level quantification is correlated to Absorb BVS residual molecular weight and can be used as a surrogate for the monitoring of the degradation of semi-crystalline polymers scaffolds.
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Campos et al. (2015) studied Bioresorbable scaffold degradation (n=40). Absorb bioresorbable vascular scaffold was evaluated on Correlation between scaffold-vessel hyper + upperechogenicity and scaffold molecular weight (correlation coefficient = 0.78, p=<0.01). Intravascular ultrasound high intensity grey level quantification (hyper + upperechogenicity) strongly correlated with Absorb scaffold residual molecular weight (r=0.78, p<0.01) in a porcine model.
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