Review demonstrates variable drug metabolism across patient populations, highlighting the role of cytochrome P450 enzymes in predicting adverse drug interactions.
The cytochrome P450 system is an evolutionary system to deal with the breakdown of endogenous and exogenous chemicals in the body. There is an increasing amount of interest in this area as new information is enabling us to understand why people metabolise drugs differently and why there is a spectrum of adverse effects in different people. Understanding the cytochrome P450 system also explains the mechanisms of some drug interactions, and enables us to predict which of these are likely to be relevant in clinical practice.
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Martin et al. (2001) studied this question.
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