HLA-G is expressed in muscle fibers in inflammatory myopathies and upregulated by interferon-gamma, suggesting a potential immunological role in local immune reactions.
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No immediate clinical implications for myopathies; leaves open HLA-G as immunomodulatory target pending validation.
We demonstrate that HLA-G, a nonclassical major histocompatibility complex class I antigen, is expressed in muscle fibers in various inflammatory myopathies. Further, interferon-gamma induces surface expression and upregulation of mRNA transcripts corresponding to different isoforms of HLA-G in myoblasts cultured from control subjects and patients. HLA-G may have important immunological functions in inflammatory myopathies and other local immune reactions as they occur during vaccination, myoblast transplantation, and gene therapy.
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Wiendl et al. (2000) studied this question.
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