Key result
Carbon dioxide insufflation of the thoracic cavity to 15 mm Hg in piglets increased heart rate from 99.6 to 155.0 beats/min and ETCO2 from 44.2 to 54.5 mm Hg.
Why the study?
Does carbon dioxide insufflation of the thoracic cavity at varying intrathoracic pressures affect hemodynamics in a piglet model?
Does carbon dioxide insufflation of the thoracic cavity at varying intrathoracic pressures affect hemodynamics in a piglet model?
Carbon dioxide insufflation of the thoracic cavity at pressures of 10 mm Hg or higher significantly increases heart rate and end-tidal CO2 in a piglet model.
Purpose: To quantify the effect of increased intrathoracic pressure (IP) on hemodynamics and to determine the optimal IP for surgery. Materials and Methods: Five male piglets weighing 30 to 32 kg were used. Each animal was anesthetized by gas inhalation with endotracheal intubation. A 5-mm laparoscopic valved trocar was inserted through the right fifth intercostal space, and insufflation using carbon dioxide gas was started. An IP of 5 mm Hg was maintained for 5 minutes, followed by a stepwise increase to 10 and 15 mm Hg for 5 minutes each. The heart rate, end-tidal CO2 (ETCO2), percutaneous saturation of O2 (SaO2), arterial blood pressure, and ECG were monitored during the procedure and measured at each IP. Results: The heart rate increased from 99.6 ± 17.5 to 96.4 ± 9.7, 118.9 ± 11.9,* and 155.0 ± 21.2* beats/min at 0, 5, 10, and 15 mm Hg, respectively. The ETCO2 increased from 44.2 ± 7.0 to 43.2 ± 8.6, 53.4 ± 12.2, and 54.5 ± 7.8* mm Hg, respectively. Arterial blood pressure decreased reciprocally from...
No takes yet. Share an insight, caveat, or question.
Sato et al. (2002) studied this question. Carbon dioxide insufflation of the thoracic cavity vs. 0 mm Hg (baseline) was evaluated on Hemodynamics (heart rate, ETCO2, arterial blood pressure). Carbon dioxide insufflation of the thoracic cavity to 15 mm Hg in piglets increased heart rate from 99.6 to 155.0 beats/min and ETCO2 from 44.2 to 54.5 mm Hg.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: