Key result
Atrial reverse peak flow velocity of the superior vena cava was positively correlated with pulmonary arterial systolic pressure (P<0.001), and an ARPV/SPV ratio >0.8 identified all subjects with PH.
Why the study?
Can Doppler flow spectra of the superior vena cava diagnose and assess the severity of acute thromboembolic pulmonary hypertension in a canine model?
Can Doppler flow spectra of the superior vena cava diagnose and assess the severity of acute thromboembolic pulmonary hypertension in a canine model?
p-value: p=<0.001
Doppler flow spectra of the superior vena cava, specifically the ARPV/SPV ratio, may provide a feasible non-invasive method to diagnose and assess the severity of acute thromboembolic pulmonary hypertension.
May support SVC Doppler for experimental PH assessment; leaves open human validation before clinical consideration.
We aimed to establish a canine model of acute thromboembolic pulmonary hypertension (ATEPH) and to explore the feasibility of diagnosing pulmonary hypertension (PH) through the Doppler flow spectra of the superior vena cava (SVC). A canine model of ATEPH was developed by infusing thrombus into the right femoral vein. The pulmonary arterial pressure was simultaneously measured via a right heart catheter with the guidance of ultrasound. The maximum systolic peak flow velocity (SPV), ventricular reverse peak flow velocity (VRPV), diastolic peak flow velocity (DPV), and atrial reverse peak flow velocity (ARPV) of the SVC were measured by transthoracic echocardiography. ATEPH was successfully established in 24 dogs (88.9%) with the pulmonary arterial systolic pressure (PASP) greater than 30 mmHg. ARPV increased significantly with the increase of PASP, and was positively correlated with PASP (P<0.001). The ARPV/SPV larger than 0.8 could be better adopted to identify all the subjects with PH in this study. The Doppler flow spectra of the SVC could be employed to assess the severity of ATEPH.
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Sun et al. (2011) studied Acute thromboembolic pulmonary hypertension (n=27). Doppler flow spectra of the superior vena cava was evaluated on Correlation of atrial reverse peak flow velocity (ARPV) with pulmonary arterial systolic pressure (PASP) (p=<0.001). Atrial reverse peak flow velocity of the superior vena cava was positively correlated with pulmonary arterial systolic pressure (P<0.001), and an ARPV/SPV ratio >0.8 identified all subjects with PH.
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