Key result
RV longitudinal strain drops acutely, recovers during adaptation, then declines chronically in canine PH models.
Why the study?
To evaluate right ventricular adaptation associated with increasing pulmonary arterial pressure using two-dimensional speckle tracking echocardiography.
Does two-dimensional speckle tracking echocardiography detect right ventricular myocardial adaptation during the progression of experimentally induced pulmonary hypertension in dogs?
Comparison
Baseline vs progressive sPAP elevations (30, 40, 50 mmHg) and chronic phase
Design
Experimental animal study
Follow-up
4 weeks
Authors
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Does not support clinical RV strain use in pulmonary hypertension; leaves open its value for tracking adaptation versus conventional parameters.
Does two-dimensional speckle tracking echocardiography detect right ventricular myocardial adaptation during the progression of experimentally induced pulmonary hypertension in dogs?
Two-dimensional speckle tracking echocardiography-derived right ventricular longitudinal strain can detect intrinsic RV myocardial contractility changes during pulmonary hypertension progression that conventional parameters miss.
Yuchi et al. (2021) studied Pulmonary hypertension (n=7). Repeated injection of microspheres vs. Baseline (pre-injection) was evaluated on Right ventricular longitudinal strain (RV-SL). In canine models of chronic pulmonary hypertension, two-dimensional speckle tracking echocardiography-derived right ventricular longitudinal strain decreased in the acute phase, increased during adaptation, and decreased again in the chronic phase.
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