Key result
Acute pulmonary hypertension (tricuspid jet velocity ≥3 m/second) during severe acute chest syndrome was associated with significantly lower survival compared to patients with lower velocities (P<0.01).
Cohort (n=70)
No
p-value: p=<0.01
Acute pulmonary hypertension during severe acute chest syndrome in sickle cell disease is associated with elevated cardiac biomarkers and increased mortality.
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Signals need for PH screening in severe ACS; leaves open whether targeted therapy improves SCD survival.
Dessap et al. (2008) conducted a cohort in Severe acute chest syndrome in sickle cell disease (n=70). Acute pulmonary hypertension (tricuspid jet velocity ≥3 m/second) vs. Tricuspid jet velocity <3 m/second was evaluated on Survival (p=<0.01). Acute pulmonary hypertension (tricuspid jet velocity ≥3 m/second) during severe acute chest syndrome was associated with significantly lower survival compared to patients with lower velocities (P<0.01).
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