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The limitations (depolymerization and Cu contamination) in the use of Cu(I)-catalyzed azide-alkyne [3 + 2] cycloadditions (CuAAC) for the selective click functionalization of polysaccharide-based systems have been efficiently surpassed using a strain-promoted approach (SPAAC). The SPAAC decoration of chitosan-g-poly(ethylene glycol) nanostructures with an immunoglobulin G under physiological conditions represents a step forward in the preparation of immunonanoparticles.
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Lallana et al. (2009) studied this question.
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