Key result
Uncontrolled ventricular rate (>100 beats/min) in mitral stenosis with atrial fibrillation was associated with higher prothrombin fragment 1+2 than controlled rate (6600 vs 5400 pmol/ml; p=0.009).
Why the study?
Does control of ventricular rate reduce systemic coagulation activation in patients with moderate to severe rheumatic mitral stenosis and atrial fibrillation?
Observational (n=100)
Does control of ventricular rate reduce systemic coagulation activation in patients with moderate to severe rheumatic mitral stenosis and atrial fibrillation?
Absolute Event Rate: 6600% vs 5400%
p-value: p=0.009
Controlling ventricular rate to ≤100 beats/min in patients with rheumatic mitral stenosis and atrial fibrillation is associated with reduced activation of the coagulation system, potentially lowering thrombosis risk.
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Rate control may lower coagulation activation in MS-AF; hypothesis-generating and requires prospective confirmation.
Yusuf et al. (2015) conducted an observational in Rheumatic mitral stenosis with atrial fibrillation (n=100). Uncontrolled ventricular rate (>100 beats/min) vs. Controlled ventricular rate (≤100 beats/min) was evaluated on Plasma concentration of prothrombin fragment 1+2 (PF1+2) (p=0.009). Uncontrolled ventricular rate (>100 beats/min) in mitral stenosis with atrial fibrillation was associated with higher prothrombin fragment 1+2 than controlled rate (6600 vs 5400 pmol/ml; p=0.009).