Key result
Magnetic resonance imaging has demonstrated that synovitis and bone erosion in rheumatoid arthritis are intimately linked through an intermediate osteitis, challenging the traditional paradigm that they are uncoupled.
MRI has significantly advanced the understanding of rheumatoid arthritis pathogenesis over the past 50 years, particularly the link between inflammation and joint damage.
May refine RA imaging strategies; leaves open prospective validation of osteitis as a therapeutic target.
Modern imaging modalities, including magnetic resonance imaging (MRI), are valuable diagnostic and therapy monitoring tools in rheumatoid arthritis (RA). This article reviewed how these imaging modalities have greatly improved our understanding of pathogenic mechanisms in RA, namely the link between inflammation and damage. For example, traditional paradigms regarding the mechanisms of joint destruction, including the idea that synovitis and damage are uncoupled, have been challenged. As the power of MRI increases, there is a need to define normality since apparently normal joints occasionally exhibit MRI evidence of synovitis in the absence of symptoms.
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McGonagle et al. (2008) conducted a review in Rheumatoid arthritis. Magnetic resonance imaging (MRI) vs. Projection radiography (x-ray) was evaluated. Magnetic resonance imaging has demonstrated that synovitis and bone erosion in rheumatoid arthritis are intimately linked through an intermediate osteitis, challenging the traditional paradigm that they are uncoupled.
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