Population
Soluble guanylyl cyclase (sGC) alpha 1 and beta 1 subunits
Comparison
Deletion mutagenesis vs Wild type soluble guanylyl cyclase enzyme
Design
Preclinical
Authors
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Separates regulatory and catalytic domains in sGC; leaves open whether NH2-terminal targeting refines NO-based cardiovascular therapies.
This study provides the first evidence that the regulatory (NO-sensitive) and catalytic (cGMP-forming) domains of soluble guanylyl cyclase are located in distinct regions of its subunits.
Wedel et al. (1995) studied this question.
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