Key result
Mildly impaired renal function in African Americans was associated with significantly lower diastolic blood pressure variability and higher plasma nitric oxide levels compared to normal renal function.
Why the study?
Is mildly impaired renal function associated with altered diastolic blood pressure variability and nitric oxide levels in African Americans?
Cross-Sectional (n=38)
Is mildly impaired renal function associated with altered diastolic blood pressure variability and nitric oxide levels in African Americans?
In African Americans, mildly impaired renal function is associated with reduced diastolic blood pressure variability and increased nitric oxide production, contrasting with findings in other populations.
Answers are grounded in this paper and cite their sources.
Should not change practice; leaves open whether nitric oxide modulates ethnic-specific diastolic variability in mild renal impairment.
We investigated the relationship between renal function, blood pressure variability (BPV), and nitric oxide (NO) in a group of African Americans with normal or mildly impaired renal function. 24-hour ambulatory blood pressure monitoring was performed, NO measured, and glomerular filtration rate (GFR) calculated in 38 African Americans. Participants were categorized as having normal (GFR > 90 mL/min per 1.73 m(2)) or mildly impaired (GFR 60-89 mL/min per 1.73 m(2)) renal function. Diastolic BPV was significantly lower in the mildly impaired renal function group. Regression analyses revealed a significant positive association between GFR and diastolic BPV for the entire study group. Plasma NO levels were significantly higher in the mildly impaired renal function group and negatively correlated with diastolic BPV. In conclusion, diastolic BPV was reduced in African Americans with mildly impaired renal function, which may be the result of increased NO production. These results conflict with previous findings in diseased and nonblack populations and could provide rationale for studying BPV early in the disease state when BP-buffering mechanisms are still preserved.
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Diaz et al. (2010) conducted a cross-sectional in Mildly impaired renal function (n=38). Mildly impaired renal function vs. Normal renal function was evaluated on Diastolic blood pressure variability and plasma nitric oxide levels. Mildly impaired renal function in African Americans was associated with significantly lower diastolic blood pressure variability and higher plasma nitric oxide levels compared to normal renal function.
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