Population
Intact rat aorta, rat myometrium, and rat vas deferens
Design
Preclinical
Authors
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May underlie differential cGMP responses in vascular versus nonvascular smooth muscle; leaves open relevance to human physiology.
The failure of nonvascular smooth muscle to relax in response to NO donors, despite cGMP elevation, may be due to a lack of PKG substrate phosphorylation, unlike in vascular smooth muscle.
Hennan et al. (2001) studied this question.
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