Population
Apolipoprotein E-deficient mice and wild-type mice evaluated at 21 or 35 weeks of age
Comparison
Western-type cholesterol-rich diet vs Normal chow
Design
Preclinical
Follow-up
21 or 35 weeks of age
Authors
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Warrants caution when using sodium nitroprusside to assess nitric oxide responsiveness; leaves open whether this mechanism contributes to human vascular disease.
In a hypercholesterolemic mouse model, impaired endothelium-dependent relaxation is partly driven by decreased sensitivity to authentic nitric oxide, which is not accurately reflected by responses to the nitric oxide donor sodium nitroprusside.
Yaghoubi et al. (2000) studied this question.
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