Key result
Pharmacological inhibition and siRNA knockdown of ROCK demonstrated that pMYPT1 (Thr853) levels and phasic contractility in human myometrium are dynamically ROCK-dependent.
ROCK-dependent phosphorylation of MYPT1 dynamically regulates phasic contractility in human myometrium, offering potential mechanistic insights for treating preterm labor.
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ROCK inhibition may modulate myometrial contractility; hypothesis-generating and should not change preterm labor practice.
Hudson et al. (2011) studied Myometrial contractility. ROCK inhibitor g-H-1152 and siRNA-mediated knockdown of ROCK1/2 was evaluated on pMYPT1 (Thr853) levels and phasic contractility. Pharmacological inhibition and siRNA knockdown of ROCK demonstrated that pMYPT1 (Thr853) levels and phasic contractility in human myometrium are dynamically ROCK-dependent.
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