Abnormal Serum Uric Acid Levels in Health and Disease: A Double-Edged Sword

Abnormal serum uric acid (UA) level is a highly prevalent condition worldwide and is increasing in the general population. This alarming epidemiological trend has enormous public health implications due to the central role of abnormal serum UA levels in the initiation, progression, and long-term effects of many metabolic and systemic diseases. Metabolic disorders are major causes of global morbidity and mortality. Altered serum UA level, both above and below the reference ranges for individual traits and contexts, is potentially harmful and described by many researchers as a double-edged sword. Concrete prevention plans in susceptible individuals and treatments to restore normal levels in individuals already affected are advocated. Lifestyle adjustment, including regular moderate physical activity, weight management, healthy eating, and regular serum UA screening are recommended for individuals susceptible to derangement in serum UA levels due to age, sex, genetics, and other acquired conditions. Public health efforts to create awareness about the menace of abnormal serum UA levels, particularly in susceptible individuals, should be encouraged.