October 18, 2013Journal of Medicinal Chemistry
Hepatitis C Virus Translation Inhibitors Targeting the Internal Ribosomal Entry Site
Key result
This review highlights approaches to block Hepatitis C virus IRES function using nucleic acid, peptide, and small molecule ligands, emphasizing subdomain IIa as a key target for translation inhibitors.
Design
Review
Authors
Discussion
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Member takes
Implication
May inform HCV antiviral design; leaves open clinical translation of subdomain IIa ligands.
Structured PICO
I
Intervention
Hepatitis C Virus Translation Inhibitors targeting the internal ribosomal entry site (IRES), including nucleic acid, peptide, and small molecule ligands
This review highlights the potential of targeting the HCV IRES subdomain IIa with small molecule inhibitors to block viral translation.
Cite This Study
Dibrov et al. (2013) conducted a review in Hepatitis C Virus. Hepatitis C Virus Translation Inhibitors was evaluated. This review highlights approaches to block Hepatitis C virus IRES function using nucleic acid, peptide, and small molecule ligands, emphasizing subdomain IIa as a key target for translation inhibitors.