Key result
Patients with acute coronary syndrome had significantly higher platelet GPVI surface expression on admission compared to those with stable angina pectoris (21.4 vs 18.6; P=0.004).
Why the study?
Is elevated platelet GPVI surface expression associated with acute coronary syndrome in patients with symptomatic CAD?
Observational (n=367)
Is elevated platelet GPVI surface expression associated with acute coronary syndrome in patients with symptomatic CAD?
Absolute Event Rate: 21.4% vs 18.6%
p-value: p=0.004
Elevated platelet GPVI surface expression is associated with acute coronary syndrome and may serve as an early thrombotic marker before myocardial ischemia is evident.
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May flag early thrombotic risk in symptomatic CAD; hypothesis-generating and should not yet change practice.
Boris Bigalke (2006) conducted an observational in Symptomatic coronary artery disease (CAD) (n=367). Acute coronary syndrome (ACS) vs. Stable angina pectoris (SAP) was evaluated on Platelet surface expression of GPVI (mean fluorescence intensity) (p=0.004). Patients with acute coronary syndrome had significantly higher platelet GPVI surface expression on admission compared to those with stable angina pectoris (21.4 vs 18.6; P=0.004).
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