November 1, 1992Journal of VirologyOpen Access

The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for function

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Population

Herpes simplex virus type 1 UL9 protein model (in vivo complementation test using transfected plasmids)

Comparison

Site-specific mutations vs Wild-type UL9 protein / replication-deficient…

Design

Preclinical

Authors

Discussion

UL9 motif mutations abolish HSV replication function; leaves open whether targeting them yields viable antivirals.

Population

Herpes simplex virus type 1 UL9 protein model (in vivo complementation test using transfected plasmids)

Intervention

Site-specific mutations (single amino acid substitutions in conserved helicase motifs and insertion mutants)

Comparator

Wild-type UL9 protein / replication-deficient null mutant

Outcome

Function of the UL9 protein in viral DNA replication (amplification of HSV origin-containing plasmids)surrogate

The conserved helicase motifs of the HSV-1 UL9 protein are essential for its function in viral DNA replication.

Martínez et al. (1992) studied this question.

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