Key result
Elevated NT-proBNP levels demonstrated significant discriminatory function for predicting major adverse cardiac events in acute myocardial infarction survivors.
Why the study?
Data on predicting post-discharge major adverse cardiac events in patients with myocardial infarction remain limited, prompting evaluation of early predictors with emphasis on multiple cardiac biomarkers.
Do cardiac biomarkers (NT-proBNP, WBC) predict major adverse cardiac events in patients with acute myocardial infarction following primary PCI?
Cohort (n=150)
No
Do cardiac biomarkers (NT-proBNP, WBC) predict major adverse cardiac events in patients with acute myocardial infarction following primary PCI?
Effect estimate: AUC 0.640 (95% CI 0.512-0.768)
p-value: p=0.025
Elevated NT-proBNP and WBC levels are independent predictors of mid-term major adverse cardiac events in patients surviving acute myocardial infarction after primary PCI.
Background: Given the number of prognostic studies, both short- and long-termed, in patients with myocardial infarction (MI), the data on predicting major adverse cardiac events (MACE) following discharge still remains limited. Aim: to identify early predictors of MACE in MI patients, that underwent Primary Percutaneous Coronary Intervention (pPCI), with special emphasis on multiple cardiac biomarkers. Materials and methods: we analysed clinical, LV functional, angiographic variables, as well cardiac troponin, a marker of myocardial necrosis, natriuretic peptide (NT-proBNP), a marker of myocardial stress, and white blood cells (WBC), as a marker of inflammation. The study population were 150 consecutive patients treated for acute myocardial infarction. Results: The average follow-up period was 31 months. In total, 26 patients suffered from at least one MACE. Multivariate logistic regression analysis identified several independent predictors: NT-proBNP (p=0,07), number of diseased vessels (p=0,027), and need for loop diuretic therapy (p=0,050). ROC curve demonstrated excellent discriminatory function for MACE of NT-proBNP and WBC (area under the curve .640, and .658, p=0.025 and 0.011 respectively). Conclusion: The combination of biomarkers for myocardial stress and inflammation improves the prediction of major adverse cardiac events in MI survivors.
No takes yet. Share an insight, caveat, or question.
Serafimov et al. (2022) conducted a cohort in Acute Myocardial Infarction (n=150). Elevated NT-proBNP vs. Normal NT-proBNP levels was evaluated on Major adverse cardiac events (MACE) (AUC 0.640, 95% CI 0.512-0.768, p=0.025). Elevated NT-proBNP levels demonstrated significant discriminatory function for predicting major adverse cardiac events in acute myocardial infarction survivors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: