Key result
A step-wise, streamlined approach to safety pharmacology throughout the drug discovery process can help predict potential adverse drug reactions and reduce attrition during clinical development.
Design
Review
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May inform early safety testing in discovery pipelines; leaves open prospective validation of reduced attrition.
Integrating highly sensitive and predictive safety pharmacology tests early and strategically in drug discovery may reduce clinical attrition and improve drug safety.
Redfern et al. (2002) reported a review. Step-wise, streamlined approach to safety pharmacology was evaluated. A step-wise, streamlined approach to safety pharmacology throughout the drug discovery process can help predict potential adverse drug reactions and reduce attrition during clinical development.
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