Key result
Fluoroquinolones, including levofloxacin, moxifloxacin, and gatifloxacin, prolong the QTc interval and carry a rare risk of Torsades de Pointes, particularly in patients with predisposing risk factors.
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Fluoroquinolones carry a risk of QTc prolongation and Torsades de Pointes, highlighting the importance of avoiding these agents in patients with predisposing risk factors and the need for rigorous postmarketing safety surveillance.
Owens et al. (2002) conducted a review in Torsades de Pointes. Fluoroquinolones was evaluated on QTc interval prolongation and Torsades de Pointes. Fluoroquinolones, including levofloxacin, moxifloxacin, and gatifloxacin, prolong the QTc interval and carry a rare risk of Torsades de Pointes, particularly in patients with predisposing risk factors.
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