Key result
Surgical anastomosis between the carotid artery and jugular vein in minipigs effectively established pulmonary arterial hypertension with mean pulmonary artery pressure ≥25 mmHg and RV impairment.
A carotid artery-jugular vein shunt in minipigs effectively establishes a large animal model of PAH with progressive RV dysfunction that can be monitored via Doppler echocardiography.
No clinical implications for PAH; leaves open validation of this large-animal model for preclinical RV research.
The continuous changes in pulmonary hemodynamic properties and right ventricular (RV) function in pulmonary arterial hypertension (PAH) have not been fully characterized in large animal model of PAH induced by a carotid artery-jugular vein shunt. A minipig model of PAH was induced by a surgical anastomosis between the left common carotid artery and the left jugular vein. The model was validated by catheter examination and pathologic analyses, and the hemodynamic features and right-ventricle functional characteristics of the model were continuously observed by Doppler echocardiography. Of the 45 minipigs who received the surgery, 27 survived and were validated as models of PAH, reflected by mean pulmonary artery pressure ≥25 mmHg, and typical pathologic changes of pulmonary arterial remodeling and RV fibrosis. Non-invasive indices of pulmonary hemodynamics (pulmonary artery accelerating time and its ratio to RV ventricular ejection time) were temporarily increased, then reduced later, similar to changes in tricuspid annular displacement. The Tei index of the RV was elevated, indicating a progressive impairment in RV function. Surgical anastomosis between carotid artery and jugular vein in a minipig is effective to establish PAH, and non-invasive hemodynamic and right-ventricle functional indices measured by Doppler echocardiography may be used as early indicators of PAH.
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Wu et al. (2015) studied Pulmonary arterial hypertension (n=45). Surgical anastomosis between the left common carotid artery and the left jugular vein was evaluated on Hemodynamic features and right-ventricle functional characteristics. Surgical anastomosis between the carotid artery and jugular vein in minipigs effectively established pulmonary arterial hypertension with mean pulmonary artery pressure ≥25 mmHg and RV impairment.
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