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April 11, 2016Journal of Visualized ExperimentsOpen Access

Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension

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Key result

Echocardiography, right heart catheterization, and pressure-volume loop analysis enable complete hemodynamic characterization of right ventricular function in rodent models of pulmonary hypertension.

Authors

ZMZhiyuan MaSt. Luke's University Health NetworkLMLan MaoDuke UniversitySRSudarshan RajagopalDuke University

Discussion

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Implication

Should not change clinical practice; extends options for hemodynamic assessment in rodent PH models.

PICO

P
Population
Pulmonary arterial hypertension
I
Intervention / Comparator
Hemodynamic characterization procedures

Limitations

  • Obtaining standard views of the right ventricle using echocardiography is challenging in the awake mouse.

Cite This Study

Ma et al. (2016) studied Pulmonary arterial hypertension. Hemodynamic characterization procedures was evaluated. Echocardiography, right heart catheterization, and pressure-volume loop analysis enable complete hemodynamic characterization of right ventricular function in rodent models of pulmonary hypertension.

synapsesocial.com/papers/6a2000a7d5e8712fdf65a8d4https://doi.org/10.3791/53335
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Echocardiographic Assessment of the Right Heart in Mice2013 · 22 citations
  2. 2Noninvasive Assessment of Murine Pulmonary Arterial Pressure2009 · 185 citations
  3. 3A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects2012 · 205 citations
  4. 4Progressive right ventricular functional and structural changes in a mouse model of pulmonary arterial hypertension2013 · 55 citations
  5. 5Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography2014 · 34 citations