Key result
SK3-1C acts as a dominant-negative suppressor of SK1, SK2, SK3, and IKCa1 channels by sequestering the channel proteins intracellularly.
Population
Mammalian cells and human tissues (lymphoid tissues, skeletal muscle, trachea, salivary gland)
Design
Preclinical
Authors
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Offers a tool to probe KCa channel regulation in models; leaves open translation to human cardiovascular therapy.
SK3-1C acts as a dominant-negative suppressor of SKCa and IKCa channels by trapping them intracellularly, providing a mechanism to modulate membrane excitability.
Kolski‐Andreaco et al. (2004) studied this question. SK3-1C expression was evaluated on Suppression of SKCa and IKCa channels. SK3-1C acts as a dominant-negative suppressor of SK1, SK2, SK3, and IKCa1 channels by sequestering the channel proteins intracellularly.
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