What question did this study set out to answer?

To determine whether the enhanced short-term postoperative analgesia provided by intrathecal morphine improves recovery and quality of life up to six months after orthopedic surgery.

May 1, 2017Journal of Pain ResearchOpen Access

The improved quality of postoperative analgesia after intrathecal morphine does not result in improved recovery and quality of life in the first 6 months after orthopedic surgery: a randomized controlled pilot study

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To determine whether the enhanced short-term postoperative analgesia provided by intrathecal morphine improves recovery and quality of life up to six months after orthopedic surgery.
Randomized, double-blind trial at an academic medical center in 49 patients undergoing total hip or knee replacement under spinal anesthesia.
Patients were randomized to receive 0.1 mg intrathecal morphine (n=16), 0.2 mg intrathecal morphine (n=16), or saline placebo (n=17) added to 3 mL 0.5% isobaric bupivacaine, with follow-up through 26 weeks.
Both intrathecal morphine groups required significantly less supplemental systemic morphine (P=0.004) and experienced significantly less pain at rest one week postoperatively (P=0.01) compared with placebo.
At hospital discharge, patients receiving 0.2 mg intrathecal morphine showed significantly greater joint pain, stiffness, and functional impairment than the 0.1 mg and placebo groups (P=0.02).
During the remaining follow-up through 6 months, recovery and quality-of-life trajectories did not differ significantly among the three study arms (P>0.2).

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Implication

Randomized double-blind trial reveals intrathecal morphine improves early analgesia without enhancing six-month recovery in joint replacement, indicating limited long-term functional benefit.

Cite This Study

Foadi et al. (2017) studied this question.

synapsesocial.com/papers/6a844c8dd7bfb55d357309f1 https://doi.org/10.2147/jpr.s135142

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Implication

Randomized double-blind trial reveals intrathecal morphine improves early analgesia without enhancing six-month recovery in joint replacement, indicating limited long-term functional benefit.

The improved quality of postoperative analgesia after intrathecal morphine does not result in improved recovery and quality of life in the first 6 months after orthopedic surgery: a randomized controlled pilot study

Key Points

Discussion

Implication

Cite This Study

The improved quality of postoperative analgesia after intrathecal morphine does not result in improved recovery and quality of life in the first 6 months after orthopedic surgery: a randomized controlled pilot study

Key Points

Discussion

Implication

Cite This Study

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