Self‐assembly by H‐bonding and by metal‐coordination of functionalized calix[4]arenes and cavitands to large supramolecular capsules is described. In addition, a new method of analyzing supramolecular recognition processes at the single molecule level is discussed. By measuring interaction forces in a hydrogen‐bonded assembly using single‐molecule force spectroscopy (SMFS), the dynamics of the self‐assembly process can be evaluated. In the future, consequent application of this new technique will influence supramolecular design principles and the use of non‐covalent interactions as construction elements in the field of nanotechnology.
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Schröder et al. (2011) studied this question.
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