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October 28, 2022International Journal of Molecular SciencesOpen Access

Hybrid Gold Nanorod-Based Nanoplatform with Chemo and Photothermal Activities for Bimodal Cancer Therapy

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Authors

LALilia ArellanoEVEva Villar‐ÁlvarezAVAlejandro Varela

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Overview

In vitro study demonstrates targeted chemo-photothermal cytotoxicity in cervical cancer cells, indicating enhanced efficacy and safety through dual-stimuli drug delivery.

Key Points

  • To optimize a gold nanorod-based core-shell platform loaded with doxorubicin and targeted with hyaluronic acid for combined chemo- and photothermal cancer therapy.
  • Synthesized a core-shell nanoplatform using gold nanorods functionalized via layer-by-layer assembly with poly(sodium 4-styrenesulfonate), doxorubicin, poly-L-lysine, and hyaluronic acid.
  • Evaluated colloidal stability across physiological conditions and assessed drug release kinetics triggered by protease exposure and external light irradiation.
  • Analyzed cellular uptake, cytotoxicity profiles, and death pathways in malignant HeLa cervical cancer cells compared with healthy 3T3-Balb fibroblast controls.
  • The engineered nanoplatform maintained colloidal stability and nanoscale dimensions while providing dual-stimuli-responsive drug release under protease and light exposure.
  • Hyaluronic acid targeting drove preferential internalization and selective cytotoxicity in HeLa cells while preserving healthy 3T3-Balb fibroblasts.
  • Combining doxorubicin delivery with photothermal excitation increased overall cell mortality, with cell death occurring primarily through an apoptotic pathway rather than necrosis.

Cite This Study

Arellano et al. (2022) studied this question.

synapsesocial.com/papers/6a844cd5c2c8a33f31f7a571https://doi.org/10.3390/ijms232113109
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